Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …

Reconstructing the phylogenetic relationships that unite all lineages (the tree of life) is a
grand challenge. The paucity of homologous character data across disparately related …

BACKGROUND The birth, death, and diversification of individuals are events that drive
biological processes across all scales. This is true whether the individuals in question …

Single-cell molecular profiling technologies are gaining rapid traction, but the manual
process by which resulting cell types are typically annotated is labor intensive and rate …

Single cell biology is currently revolutionizing developmental and evolutionary biology,
revealing new cell types and states in an impressive range of biological systems. With the …

An accurate reconstruction of the eukaryotic tree of life is essential to identify the innovations
underlying the diversity of microbial and macroscopic (eg, plants and animals) eukaryotes …

The accelerating growth of data and knowledge in evolutionary biology is indisputable.
Despite this rapid progress, information remains scattered, poorly documented and in …

Phylogenies are increasingly prominent across all of biology, especially as DNA sequencing
makes more and more trees available. However, their utility is compromised by widespread …

The advancement of single-cell RNA-sequencing technologies has led to an explosion of
cell type definitions across multiple organs and organisms. While standards for data and …

The phylogeny and timescale of life are becoming better understood as the analysis of
genomic data from model organisms continues to grow. As a result, discoveries are being …