Background Osteoarthritis (OA) is the most common degenerative joint disease primarily
characterized by cartilage destruction. The aim of this study was to investigate the role …

Background Osteoarthritis (OA) is the most common joint disease and is the leading cause
of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) …

Purpose Recent scientific reports have revealed a close association between ferroptosis
and the occurrence and development of osteoarthritis (OA). Nevertheless, the precise …

Osteoarthritis (OA) is a type of arthritis that causes joint pain and limited mobility. In recent
years, some studies have shown that the pathological process of OA chondrocytes is related …

Objective Articular chondrocyte activation, involving aberrant proliferation and
prehypertrophic differentiation, is essential for osteoarthritis (OA) initiation and progression …

Background Osteoarthritis (OA) is a complex process comprised of mechanical load,
inflammation, and metabolic factors. It is still unknown that if chondrocytes undergo …

Objective Nucleus pulposus (NP) plays a central role in disc degeneration pathogenesis,
however, as a heterogeneous tissue, cell subsets in NP and their corresponding biological …

Objectives Understanding the molecular mechanisms underlying human cartilage
degeneration and regeneration is helpful for improving therapeutic strategies for treating …

Aims Chondrocyte apoptosis is the most common pathological feature of cartilage in
osteoarthritis (OA). Excessive mechanical stress can induce chondrocyte apoptosis and …

Introductions Excessive mechanical stress is closely associated with cell death in various
conditions. Exposure of chondrocytes to excessive mechanical loading leads to a catabolic …