Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Epigenetic alterations such as DNA methylation defects and aberrant covalent histone
modifications occur within all cancers and are selected for throughout the natural history of …

Epigenetics refers to heritable molecular determinants of phenotype independent of DNA
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …

Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Alterations in the genome and the epigenome are common in most cancers. Changes in
epigenetic signatures, including aberrant DNA methylation and histone deacetylation, are …

Interest in epigenetics is now booming in all the biomedical fields. Initially, interest was
sparked within the field of cancer research with the finding of global DNA hypomethylation …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Epigenetic alterations are associated with normal biological processes such as aging or
differentiation. Changes in global epigenetic signatures, together with genetic alterations …

Epigenetic alterations are considered to be very influential in both the normal and disease
states of an organism. These alterations include methylation, acetylation, phosphorylation …

Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …