Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

Mammalian lifespan differs by> 100 fold, but the mechanisms associated with such longevity
differences are not understood. Here, we conducted a study on primary skin fibroblasts …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Most organisms experience changes in regenerative abilities through their lifespan. During
aging, numerous tissues exhibit a progressive decline in homeostasis and regeneration that …

While some animals, such as planaria and hydra, appear to be capable of seemingly
endless cycles of regeneration, most animals experience a gradual decline in fitness and …

Aging is characterized by a general decline in cellular function, which ultimately will affect
whole body homeostasis. Although DNA damage and oxidative stress all contribute to …

Many tissues and organ systems in metazoans have the intrinsic capacity to regenerate,
which is driven and maintained largely by tissue-resident somatic stem cell populations …

Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …

Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose
regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient …