The role of telomerase in breast Cancer's response to Therapy

E Judasz, N Lisiak, P Kopczyński, M Taube… - International journal of …, 2022 - mdpi.com
Currently, breast cancer appears to be the most widespread cancer in the world and the
most common cause of cancer deaths. This specific type of cancer affects women in both …

Telomerase as a useful target in cancer fighting—the breast cancer case

H Holysz, N Lipinska, A Paszel-Jaworska, B Rubis - Tumor biology, 2013 - Springer
Telomerase was initially considered as a relevant factor distinguishing cancer from normal
cells. During detailed studies, it appeared that its expression and activity is not only limited to …

Assessment of telomerase as drug target in breast cancer

RK Jaiswal, PK Yadava - Journal of Biosciences, 2020 - Springer
Telomerase is a specialized enzyme which maintains telomere length at the extreme end of
the chromosome. Over 90% of all cases of cancer show high expression of telomerase while …

Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells

MA Cerone, JA Londoño-Vallejo, C Autexier - Molecular cancer therapeutics, 2006 - AACR
Breast cancer is the most common malignancy among women. Current therapies for breast
tumors are based on the use of chemotherapeutic drugs that are quite toxic for the patients …

Telomerase as a diagnostic and therapeutic target for cancer

LA Doyle, WE Highsmith - Expert review of anticancer therapy, 2002 - Taylor & Francis
Telomerase is a ribonucleoprotein enzyme responsible for the elongation of telomeres at the
ends of chromosomes. It is widely expressed in most cancers, while absent from most …

Telomeres and telomerase: understanding basic structure and potential new therapeutic strategies targeting it in the treatment of cancer

K Sekhri - Journal of Postgraduate Medicine, 2014 - journals.lww.com
The impact of cancer on humanity is huge and a great deal of research is going on
worldwide to find novel therapeutic targets. Telomerase is one such exciting target …

Telomerase and breast cancer

BS Herbert, WE Wright, JW Shay - Breast cancer research, 2001 - Springer
Current therapies for breast cancer include treatments that are toxic and often result in drug
resistance. Telomerase, a cellular reverse transcriptase that maintains the ends of …

Applications of telomerase research in the fight against cancer

KE McKenzie, CB Umbricht, S Sukumar - Molecular medicine today, 1999 - cell.com
Telomerase, an enzyme that confers immortality upon cells and that is active in the majority
of human tumors, has emerged as a powerful new marker and potential prognostic indicator …

The secrets of telomerase: retrospective analysis and future prospects

S Kamal, M Junaid, A Ejaz, I Bibi, MSH Akash… - Life Sciences, 2020 - Elsevier
Telomerase plays a significant role to maintain and regulate the telomere length, cellular
immortality and senescence by the addition of guanine-rich repetitive sequences. Chronic …

Telomerase as a cancer target. Development of new molecules

DL Mengual Gómez, RG Armando… - Current Topics in …, 2016 - ingentaconnect.com
Telomeres are the terminal part of the chromosome containing a long repetitive and
noncodifying sequence that has as function protecting the chromosomes. In normal cells …