FAM19A5 in vascular aging and osteoporosis: mechanisms and the “calcification paradox”

J Zheng, J He, H Li - Ageing Research Reviews, 2024 - Elsevier
Aging induces a progressive decline in the vasculature's structure and function. Vascular
aging is a determinant factor for vascular ailments in the elderly. FAM19A5, a recently …

Circulating FAM19A5 level is associated with the presence and severity of coronary artery disease

F Ma, J Hao, J Zhao, D Liu, H Cao, B Yang… - International Journal of …, 2022 - Elsevier
Background Family with sequence similarity 19 member A5 (FAM19A5) has been identified
as a novel adipokine that plays an important role in inhibiting inflammation and vascular …

Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knock-out, and LacZ knock-in mice

H Kwak, EH Cho, EB Cho, YN Lee, A Shahapal… - bioRxiv, 2020 - biorxiv.org
Abstract FAM19A5 (also called TAFA5) is a novel secretory protein that is primarily
expressed in the brain. However, a recent study reported that FAM19A5 is an adipocyte …

Can Adipokine FAM19A5 Be a Biomarker of Metabolic Disorders?

A Wesołek-Leszczyńska, K Pastusiak… - Diabetes, Metabolic …, 2024 - Taylor & Francis
Aim One of the most critical functions of adipose tissue is the production of adipokines, ie,
numerous active substances that regulate metabolism. One is the newly discovered …

Association of serum FAM19A5 with metabolic and vascular risk factors in human subjects with or without type 2 diabetes

YB Lee, HJ Hwang, JA Kim, SY Hwang… - Diabetes and …, 2019 - journals.sagepub.com
Objectives: A recent experimental study revealed that family with sequence similarity 19
[chemokine (CC motif)-like] member A5 (FAM19A5), a novel secreted adipokine, has …

Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease

FA Yari, P Shabani, S Karami, N Sarmadi… - BMC endocrine …, 2021 - Springer
Background Family with sequence similarity 19 (chemokine (CC motif)-like) member A5
(FAM19A5) is a newly identified adipokine. There is a limited number of studies linking …

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

EM van der Ark-Vonk, MV Puijk, G Pasterkamp… - Current Atherosclerosis …, 2024 - Springer
Abstract Purpose of Review Fatty acid-binding protein 4 (FABP4) plays a role in lipid
metabolism and cardiovascular health. In this paper, we cover FABP4 biology, its …

Novel adipokine, FAM19A5, inhibits neointima formation after injury through sphingosine-1-phosphate receptor 2

Y Wang, D Chen, Y Zhang, P Wang, C Zheng… - Circulation, 2018 - Am Heart Assoc
Background: Obesity plays crucial roles in the development of cardiovascular diseases.
However, the mechanisms that link obesity and cardiovascular diseases remain elusive …

Endothelial FAM3A positively regulates post-ischaemic angiogenesis

W Xu, M Liang, Y Zhang, K Huang, C Wang - EBioMedicine, 2019 - thelancet.com
Background Angiogenesis improves reperfusion to the ischaemic tissue after vascular
obstruction. The underlying molecular mechanisms of post-ischaemic angiogenesis are not …

Fatty acid-binding protein 4 (FABP4): pathophysiological insights and potent clinical biomarker of metabolic and cardiovascular diseases

M Furuhashi, S Saitoh… - Clinical medicine …, 2014 - journals.sagepub.com
Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …