Abnormal α-synuclein aggregation is a key pathological feature of a group of
neurodegenerative diseases known as synucleinopathies, which include Parkinson's …

The deposition of the abundant presynaptic brain protein α-synuclein as fibrillary aggregates
in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders …

Objectives Currently, the exact reasons why different α‐synucleinopathies exhibit variable
pathologies and phenotypes are still unknown. A potential explanation may be the existence …

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding
and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies …

Misfolded alpha-synuclein (αSyn) aggregates are a hallmark event in Parkinson's disease
(PD) and other synucleinopathies. Recently, αSyn seed amplification assays (αSyn-SAAs) …

Parkinson disease (PD) is the second most common neurodegenerative disease, and the
most common synucleinopathy, as alpha-synuclein (α-syn), a prion-like protein, plays an …

Several neurodegenerative disorders are characterized by intracellular protein
accumulations or inclusions, such as the Lewy bodies of Parkinson's disease. Although little …

To date there is no accepted clinical diagnostic test for Parkinson's disease (PD) based on
biochemical analysis of blood or cerebrospinal fluid (CSF). α‐Synuclein (α‐syn) protein has …

The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia
with Lewy bodies would be aided by the availability of assays for the pathogenic disease …

Background and Objectives Robust biomarkers that can mirror Parkinson disease (PD) are
of great significance. In this study, we present a novel approach to investigate disease …