[HTML][HTML] Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

N Brodyagin, M Katkevics, V Kotikam… - Beilstein journal of …, 2021 - beilstein-journals.org
Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Peptide nucleic acids (PNAs), a chemical overview

A Porcheddu, G Giacomelli - Current medicinal chemistry, 2005 - ingentaconnect.com
Peptide nucleic acid (PNA) is a nucleic acid analogue and a fully synthetic DNA/RNA-
recognising ligand with a neutral peptide-like backbone. In spite of the large change on the …

Peptide nucleic acids analogs and derivatives

KN Ganesh, PE Nielsen - Current Organic Chemistry, 2000 - ingentaconnect.com
Peptide Nucleic Acids (PNA) invented ten years ago are emerging rapidly as useful
molecules in DNA hybridization and antisense techniques. Although therapeutic drugs …

Recent advances in chemical modification of peptide nucleic acids

E Rozners - Journal of nucleic acids, 2012 - Wiley Online Library
Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology.
Although PNA recognizes single‐stranded nucleic acids with exceptionally high affinity and …

Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future

A Ray, B Nordén - The FASEB Journal, 2000 - Wiley Online Library
Synthetic molecules that can bind with high sequence specificity to a chosen target in a
gene sequence are of major interest in medicinal and biotechnological contexts. They show …

Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

J Saarbach, PM Sabale, N Winssinger - Current opinion in chemical …, 2019 - Elsevier
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …

Targeting double stranded DNA with peptide nucleic acid (PNA)

PE Nielsen - Current medicinal chemistry, 2000 - ingentaconnect.com
PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone
which can be used to target double stranded DNA with high sequence specificity. PNA …

Versatility of peptide nucleic acids (PNA s): Role in chemical biology, drug discovery, and origins of life

C Sharma, SK Awasthi - Chemical biology & drug design, 2017 - Wiley Online Library
This review briefly discussed nomenclature, synthesis, chemistry, and biophysical properties
of a plethora of PNA derivatives reported since the discovery of aeg PNA. Different synthetic …

Evolution of peptide nucleic acid with modifications of its backbone and application in biotechnology

A Das, B Pradhan - Chemical Biology & Drug Design, 2021 - Wiley Online Library
Peptide nucleic acids (PNAs) are getting prodigious interest currently in the biomedical and
diagnostic field as an extremely powerful tool because of their potentiality to hybridize with …

The peptide nucleic acids, efficient tools for molecular diagnosis

F Pellestor, P Paulasova - International journal of …, 2004 - spandidos-publications.com
Peptide nucleic acids (PNAs) are synthetic analogs of DNA that hybridize with
complementary DNAs or RNAs with high affinity and specificity, essentially because of an …