Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Telomeres are gene sequences present at chromosomal ends and are responsible for
maintaining genome integrity. Telomere length is maximum at birth and decreases …

Biomarkers of aging are essential to predict mortality and aging‐related diseases.
Paradoxically, age itself imposes a limitation on the use of known biomarkers of aging …

Telomere attrition is a proposed hallmark of aging. To evaluate the association of telomere
length (TL) with chronological age across the human lifespan, we conducted a systematic …

Telomeres in telomerase-negative cells shorten during DNA replication in vitro due to
numerous causes including the inability of DNA polymerases to fully copy the lagging …

Telomeres, the tandem-repeated hexamers at the termini of mammalian chromosomes, form
protective complexes in association with specific proteins that together with telomerase, a …

Telomeres, the DNA–protein structures located at the ends of chromosomes, have been
proposed to act as a biomarker of aging. In this review, the human evidence that telomere …

Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …

OBJECTIVE: To provide a systematic review of the relationship between age and leukocyte
telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic …

Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-
dimensional structure, they protect the coding DNA and ensure appropriate separation of …