Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Aging is a universal phenomenon in all biological organisms, defined by the loss of
reproductive capacity and a progressive decline in fitness. In humans, aging is further …

Metformin is a safe, effective and useful drug for glucose management in patients with
diabetes. However in recent years, more attention has been paid to the possibility of using …

Even though the inevitable process of aging by itself cannot be considered a disease, it is
directly linked to life span and is the driving force behind all age-related diseases. It is an …

Apart from being a safe, effective and globally affordable glucose-lowering agent for the
treatment of diabetes, metformin has earned much credit in recent years as a potential anti …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Aging has been targeted by genetic and dietary manipulation and by drugs in order to
increase lifespan and health span in numerous models. Metformin, which has demonstrated …

In a world where the population is ageing, there is growing interest and demand for research
evaluating strategies that address the ageing process. After 60 years of successful use of …

Administration of metformin increases healthspan and lifespan in model systems, and
evidence from clinical trials and observational studies suggests that metformin delays a …