The DNA damage response (DDR) pathway is a cardinal cellular stress response
mechanism that during cancer development follows an antagonistic pleiotropy mode of …

Chemotherapy and radiotherapy regimens are designed primarily to induce DNA damage to
kill cancer cells. DNA damage response (DDR) proteins recognize and repair a variety of …

The subjection of DNA to numerous lethal damages is threatening for the stability and
integrity of the whole body genome. DNA damage response (DDR) is a critical …

Autophagy and the DNA damage response (DDR) are biological processes essential for
cellular and organismal homeostasis. Herein, we summarize and discuss emerging …

Autophagy is an evolutionarily conserved process that captures aberrant intracellular
proteins and/or damaged organelles for delivery to lysosomes, with implications for cellular …

The cancer-relevance of autophagy is still debated, since this process is a very dynamic and
context-dependent mechanism that can acts paradoxically both as tumor suppressor (by …

Several cellular survival pathways help buffer cells against environmental stresses. The
DNA damage response (DDR) activates a highly conserved signaling cascade that (1) …

DNA lesions, constantly produced by endogenous and exogenous sources, activate the
DNA damage response (DDR), which involves detection, signaling and repair of the …

Autophagy is a highly conserved pathway in eukaryotic cells induced by a variety of stimuli
to remove superfluous or damaged organelles or abnormally aggregated proteins to …

In recent years, a considerable correlation has emerged between autophagy and genome
integrity. A range of mechanisms appear to be involved where autophagy participates in …