The lifespan is influenced by adverse childhood experiences that create predispositions to
poor health outcomes. Here we propose an allostatic framework of childhood experiences …

Adversity in childhood has effects on mental and physical health, not only in childhood but
across the lifespan. A chief task of our research has been to define the pathways by which …

How do adverse childhood experiences get 'under the skin'and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …

The concepts of allostasis (stability through adaptation) and accumulated life stress
(McEwen's allostatic load) aim to understand childhood and adult outcomes. Chronic …

Advances in fields of inquiry as diverse as neuroscience, molecular biology, genomics,
developmental psychology, epidemiology, sociology, and economics are catalyzing an …

Background Adverse psychosocial exposures in early life, namely experiences such as child
maltreatment, caregiver stress or depression, and domestic or community violence, have …

Research relating stress to health has progressed from anecdotal evidence in the 1930s
and 1940s to complex multivariate models that identify underlying longitudinal mechanisms …

Identification of genetic, experiential, and environmental risk factors that contribute to
vulnerability for untoward health outcomes is a major target of behavioral and biomedical …

This Technical Report was retired November 2021. Advances in fields of inquiry as diverse
as neuroscience, molecular biology, genomics, developmental psychology, epidemiology …

Socially disadvantaged individuals are at greater risk for simultaneously being exposed to
adverse social and environmental conditions. Although the mechanisms underlying joint …