Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …

Stable maintenance of gene regulatory programs is essential for normal function in
multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are …

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by ectopic
expression of different transcription factors, classically Oct4 (also known as Pou5f1), Sox2 …

Methylation at the 5′ position of cytosine in DNA has important roles in genome function
and is dynamically reprogrammed during early embryonic and germ cell development. The …

The functionality of stem cells declines during ageing, and this decline contributes to ageing-
associated impairments in tissue regeneration and function. Alterations in developmental …

Progenitor cells maintain self-renewing tissues throughout life by sustaining their capacity
for proliferation while suppressing cell cycle exit and terminal differentiation,. DNA …

DNA methylation is a major epigenetic modification of the genome that regulates crucial
aspects of its function. Genomic methylation patterns in somatic differentiated cells are …

A formidable challenge in neural repair in the adult central nervous system (CNS) is the long
distances that regenerating axons often need to travel in order to reconnect with their …

Epigenetic modifications of the genome are generally stable in somatic cells of multicellular
organisms. In germ cells and early embryos, however, epigenetic reprogramming occurs on …

Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming
involves global epigenetic remodelling. Whereas several proteins are known to regulate …