Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics

DT Paik, M Chandy, JC Wu - Pharmacological reviews, 2020 - ASPET
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

Induced pluripotent stem cells as a disease modeling and drug screening platform

AD Ebert, P Liang, JC Wu - Journal of cardiovascular …, 2012 - journals.lww.com
Induced pluripotent stem cells (iPSCs) hold great hopes for therapeutic application in
various diseases. Although ongoing research is dedicated to achieving clinical translation of …

Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production

D Thomas, NJ Cunningham, S Shenoy… - Cardiovascular …, 2022 - academic.oup.com
Manifestations of cardiovascular diseases (CVDs) in a patient or a population differ based
on inherent biological makeup, lifestyle, and exposure to environmental risk factors. These …

Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine: a scientific statement from the American Heart Association

K Musunuru, F Sheikh, RM Gupta… - Circulation: Genomic …, 2018 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

Induced pluripotent stem cells in cardiovascular drug discovery

M Mercola, A Colas, E Willems - Circulation research, 2013 - Am Heart Assoc
The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …

Human induced pluripotent stem cell–derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes

I Karakikes, M Ameen, V Termglinchan… - Circulation research, 2015 - Am Heart Assoc
Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …

Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine

E Matsa, JH Ahrens, JC Wu - Physiological Reviews, 2016 - journals.physiology.org
Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human
disease modeling, with an enormous potential to serve as paradigm shifting platforms for …

Human iPSC modeling of heart disease for drug development

AP Hnatiuk, F Briganti, DW Staudt, M Mercola - Cell chemical biology, 2021 - cell.com
Human induced pluripotent stem cells (hiPSCs) have emerged as a promising platform for
pharmacogenomics and drug development. In cardiology, they make it possible to produce …

Utility of iPSC-derived cells for disease modeling, drug development, and cell therapy

MW Nicholson, CY Ting, DZH Chan, YC Cheng… - Cells, 2022 - mdpi.com
The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …

Human stem cells for modeling heart disease and for drug discovery

E Matsa, PW Burridge, JC Wu - Science translational medicine, 2014 - science.org
A major research focus in the field of cardiovascular medicine is the prospect of using stem
cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent …