The mechanistic target of rapamycin (mTOR) signaling pathway plays a major role in key
cellular processes including metabolism and differentiation; however, the role of mTOR in …

Alzheimer's disease (AD) is a late-onset dementia characterized by the deposition of
amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss …

TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for
Alzheimer's disease (AD). As microglial responses modulated by TREM2 are central to AD …

Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to
brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ) …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that
recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) …

Background Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and
lipoprotein binding receptor expressed by cells of myeloid origin. Homozygous TREM2 …

Overactivated microglia and neuroinflammation are considered to play a crucial role in the
progression of Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells-2 …

Alzheimer's disease (AD), the most common form of dementia, is characterized by the
abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as …

TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2
impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of …

As the most common type of neurodegenerative disease, Alzheimer's disease (AD) is
characterized by the accumulation of amyloid-β peptide (Aβ) within the brain. Triggering …