Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old

L Sordo, T Qian, SA Bukhari, KM Nguyen… - Acta …, 2023 - Springer
Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion
characterized by neuronal loss and astrogliosis in subiculum and CA1 subfield of …

Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non …

WD Brenowitz, SE Monsell, FA Schmitt… - Journal of …, 2014 - content.iospress.com
Hippocampal sclerosis of aging (HS-Aging) neuropathology was observed in more than
15% of aged individuals in prior studies. However, much remains unknown about the clinical …

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

PT Nelson, CD Smith, EL Abner, BJ Wilfred… - Acta …, 2013 - Springer
Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of
elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria …

Hippocampal sclerosis and TDP‐43 pathology in aging and A lzheimer disease

S Nag, L Yu, AW Capuano, RS Wilson… - Annals of …, 2015 - Wiley Online Library
Objective To investigate the association of hippocampal sclerosis (HS) with TAR‐DNA
binding protein of 43kDa (TDP‐43) and other common age‐related pathologies, dementia …

Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease

R Ihara, BD Vincent, MR Baxter, EE Franklin… - Annals of …, 2018 - Wiley Online Library
Objective To characterize the pattern of neuron loss in hippocampal sclerosis of aging (HS‐
Aging) and age‐related diseases and to evaluate its contribution to cognitive impairment in …

Hippocampal sclerosis of aging can be segmental: two cases and review of the literature

ET Ighodaro, GA Jicha, FA Schmitt… - … of Neuropathology & …, 2015 - academic.oup.com
Hippocampal sclerosis of aging (HS-Aging) is a neurodegenerative disease that mimics
Alzheimer disease (AD) clinically and has a prevalence rivaling AD in advanced age …

Hippocampal sclerosis, hippocampal neuron loss patterns and TDP‐43 in the aged population

SRK Hokkanen, S Hunter, TM Polvikoski… - Brain …, 2018 - Wiley Online Library
Hippocampal neuron loss is a common neuropathological feature in old age with various
underlying etiologies. Hippocampal sclerosis of aging (HS‐Aging) is neuropathologically …

Hippocampal sclerosis in advanced age: clinical and pathological features

PT Nelson, FA Schmitt, Y Lin, EL Abner, GA Jicha… - Brain, 2011 - academic.oup.com
Hippocampal sclerosis is a relatively common neuropathological finding (∼ 10% of
individuals over the age of 85 years) characterized by cell loss and gliosis in the …

Utility of MRI in the identification of hippocampal sclerosis of aging

DC Woodworth, HL Nguyen, Z Khan… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Hippocampal sclerosis of aging (HS) is a common pathology often
misdiagnosed as Alzheimer's disease. We tested the hypothesis that participants with HS …

Hippocampal sclerosis in the oldest old: a Finnish population-based study

M Kero, A Raunio, T Polvikoski… - Journal of …, 2018 - content.iospress.com
Background: There are only few population-based studies that have systemically
investigated the prevalence of hippocampal sclerosis (HS) in the very old. The frequency of …