The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia
Background Population-based autopsy studies provide valuable insights into the causes of
dementia but are limited by sample size and restriction to specific populations …
dementia but are limited by sample size and restriction to specific populations …
Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
Background We have undertaken a large unselected, community-based neuropathology
study in an elderly (70-103 years) UK population in relation to prospectively evaluated …
study in an elderly (70-103 years) UK population in relation to prospectively evaluated …
Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
Z Arvanitakis, AW Capuano, SE Leurgans… - The Lancet …, 2016 - thelancet.com
Background Few data on the pathology of cerebral vessel disease, dementia, and cognition
are available. We examined the association of cerebral atherosclerosis and …
are available. We examined the association of cerebral atherosclerosis and …
Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic-and community-based samples
We examined the relationships between Alzheimer's disease neuropathologic change
(ADNC), Lewy body disease (LBD), and vascular brain injury (VBI) in 2 large autopsy …
(ADNC), Lewy body disease (LBD), and vascular brain injury (VBI) in 2 large autopsy …
METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for …
M Dichgans, J Wardlaw, E Smith, V Zietemann… - Alzheimer's & …, 2016 - Elsevier
Dementia is a global problem and major target for health care providers. Although up to 45%
of cases are primarily or partly due to cerebrovascular disease, little is known of these …
of cases are primarily or partly due to cerebrovascular disease, little is known of these …
Where vascular meets neurodegenerative disease
JA Schneider, DA Bennett - Stroke, 2010 - Am Heart Assoc
Vascular and neurodegenerative disease commonly cooccur in older persons. We review
findings from the Rush Religious Orders Study and Memory and Aging Project. Both studies …
findings from the Rush Religious Orders Study and Memory and Aging Project. Both studies …
Mid‐life and late‐life vascular risk factor burden and neuropathology in old age
Objective To determine whether vascular risk factor burden in mid‐or late‐life associates
with postmortem vascular and neurodegenerative pathologies in a community‐based …
with postmortem vascular and neurodegenerative pathologies in a community‐based …
The Nun Study: risk factors for pathology and clinical-pathologic correlations
JA Mortimer - Current Alzheimer Research, 2012 - ingentaconnect.com
The Nun Study was the first cohort study to enroll and follow a large, well-defined population
that included demented and non-demented participants, all of whom agreed to donate their …
that included demented and non-demented participants, all of whom agreed to donate their …
Epidemiological neuropathology: the MRC cognitive function and aging study experience
We here describe the study-design major findings from the neuropathological component of
the Medical Research Council Cognitive Function and Aging Study (MRC CFAS). MRC …
the Medical Research Council Cognitive Function and Aging Study (MRC CFAS). MRC …
Much of late life cognitive decline is not due to common neurodegenerative pathologies
Objective The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy
body disease accumulate in the brains of older persons with and without dementia, but the …
body disease accumulate in the brains of older persons with and without dementia, but the …