Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …

Differences in chromatin organization are key to the multiplicity of cell states that arise from a
single genetic background, yet the landscapes of in vivo tissues remain largely uncharted …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Post-translational modifications of histone proteins and exchanges of histone variants of
chromatin are central to the regulation of nearly all DNA-templated biological processes …

Genetic material in the nucleus governs mechanisms related to cell proliferation,
differentiation, and function. Thus, senescence and aging are directly tied to the change of …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays
important roles in normal physiology and tumor suppression, but accumulation of senescent …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Regulation of gene expression is linked to the organization of the genome. With age,
chromatin alterations occur on all levels of genome organization, accompanied by changes …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …