X Fan, AJ Waardenberg, M Demuth… - … and Cellular Biology, 2020 - Am Soc Microbiol
The extensive array of basic helix-loop-helix (bHLH) transcription factors and their combinations as dimers underpin the diversity of molecular function required for cell type …
Y Gou, T Zhang, J Xu - Current topics in developmental biology, 2015 - Elsevier
Craniofacial morphogenesis is driven by spatial–temporal terrains of gene expression, which give rise to stereotypical pattern formation. Transcription factors are key cellular …
JE Hooper, W Feng, H Li, SM Leach, T Phang… - Developmental …, 2017 - Elsevier
The rapid increase in gene-centric biological knowledge coupled with analytic approaches for genomewide data integration provides an opportunity to develop systems-level …
Twist1 and Twist2 are highly conserved members of the Twist subfamily of bHLH proteins responsible for the transcriptional regulation of the developmental programs in …
During development, transcription factors select distinct gene programs, providing the necessary regulatory complexity for temporal and tissue-specific gene expression. How …
L Li, P Cserjesi, EN Olson - Developmental biology, 1995 - Elsevier
Transcription factors belonging to the basic helix–loop–helix (bHLH) family have been shown to control differentiation of a variety of cell types. Tissue-specific bHLH proteins …
The mammalian HoxD cluster lies between two topologically associating domains (TADs) matching distinct enhancer-rich regulatory landscapes. During limb development, the …
AT Chang, Y Liu, K Ayyanathan, C Benner… - Genes & …, 2015 - genesdev.cshlp.org
Basic helix–loop–helix (bHLH) transcription factors recognize the canonical E-box (CANNTG) to regulate gene transcription; however, given the prevalence of E-boxes in a …
The head represents the most complex part of the body and a distinctive feature of the vertebrate body plan. This intricate structure is assembled during embryonic development in …