The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

A Pišlar, A Mitrović, J Sabotič, U Pečar Fonović… - PLoS …, 2020 - journals.plos.org
Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into
humans, causing highly prevalent and severe respiratory diseases, often with fatal …

Host cell proteases: critical determinants of coronavirus tropism and pathogenesis

JK Millet, GR Whittaker - Virus research, 2015 - Elsevier
Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses
that infect a wide range of avian and mammalian species, including humans. The …

Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63

Z Chen, Y Wang, K Ratia, AD Mesecar… - Journal of …, 2007 - Am Soc Microbiol
ABSTRACT Human coronavirus NL63 (HCoV-NL63), a common human respiratory
pathogen, is associated with both upper and lower respiratory tract disease in children and …

Priming time: how cellular proteases arm coronavirus spike proteins

M Hoffmann, H Hofmann-Winkler… - Activation of viruses by host …, 2018 - Springer
Coronaviruses are enveloped RNA viruses that infect mammals and birds. Infection of
humans with globally circulating human coronaviruses is associated with the common cold …

Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases

MA Clementz, Z Chen, BS Banach, Y Wang… - Journal of …, 2010 - Am Soc Microbiol
Coronaviruses encode multifunctional proteins that are critical for viral replication and for
blocking the innate immune response to viral infection. One such multifunctional domain is …

Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design

X Xue, H Yu, H Yang, F Xue, Z Wu, W Shen, J Li… - Journal of …, 2008 - Am Soc Microbiol
Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide
spectrum of diseases. The coronavirus main protease (Mpro), which plays a pivotal role in …

Design of wide-spectrum inhibitors targeting coronavirus main proteases

H Yang, W Xie, X Xue, K Yang, J Ma, W Liang… - PLoS …, 2005 - journals.plos.org
The genus Coronavirus contains about 25 species of coronaviruses (CoVs), which are
important pathogens causing highly prevalent diseases and often severe or fatal in humans …

Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus

YM Báez-Santos, AM Mielech, X Deng, S Baker… - Journal of …, 2014 - Am Soc Microbiol
The papain-like protease (PLpro) domain from the deadly Middle East respiratory syndrome
coronavirus (MERS-CoV) was overexpressed and purified. MERS-CoV PLpro constructs …

The recent outbreaks of human coronaviruses: A medicinal chemistry perspective

T Pillaiyar, LL Wendt, M Manickam… - Medicinal research …, 2021 - Wiley Online Library
Coronaviruses (CoVs) infect both humans and animals. In humans, CoVs can cause
respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal …

Drug design targeting the main protease, the Achilles' heel of coronaviruses

H Yang, M Bartlam, Z Rao - Current pharmaceutical design, 2006 - ingentaconnect.com
Coronaviruses (CoVs), a genus containing about 26 known species to date, cause highly
prevalent diseases and are often severe or fatal in humans and animals. In 2003, a …