Development, Characterization, and Evaluation of SLN‐Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal …
Background. Chemotherapeutic drugs cause severe toxicities if administered unprotected,
without proper targeting, and controlled release. In this study, we developed topotecan‐(TPT …
without proper targeting, and controlled release. In this study, we developed topotecan‐(TPT …
Particle and gel characterization of irinotecan-loaded double-reverse thermosensitive hydrogel
The irinotecan-loaded double-reverse thermosensitive hydrogel (DRTH) is a dispersed
system of irinotecan-loaded solid lipid nanoparticles (SLN) in a thermosensitive hydrogel. To …
system of irinotecan-loaded solid lipid nanoparticles (SLN) in a thermosensitive hydrogel. To …
Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration
Intravenously administered for the treatment of rectum cancer, irinotecan produces severe
side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double …
side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double …
A novel core-shell lipid nanoparticle for improving oral administration of water soluble chemotherapeutic agents: inhibited intestinal hydrolysis and enhanced …
T Wang, L Shen, Z Zhang, H Li, R Huang, Y Zhang… - Drug Delivery, 2017 - Taylor & Francis
The oral administration of water-soluble chemotherapeutical agents is limited by their
serious gastrointestinal side effects, instability at intestinal pH, and poor absorption. Aiming …
serious gastrointestinal side effects, instability at intestinal pH, and poor absorption. Aiming …
Orally delivered solid lipid nanoparticles of irinotecan coupled with chitosan surface modification to treat colon cancer: preparation, in-vitro and in-vivo evaluations
NA Bhaskaran, SR Jitta, SP Cheruku, N Kumar… - International Journal of …, 2022 - Elsevier
Irinotecan-loaded solid lipid nanoparticles (IRI-SLNs) was formulated and tested for its
potential activity against colon cancer. IRI-SLNs were prepared by applying the principles of …
potential activity against colon cancer. IRI-SLNs were prepared by applying the principles of …
Enhanced antitumor effects by docetaxel/LL37-loaded thermosensitive hydrogel nanoparticles in peritoneal carcinomatosis of colorectal cancer
R Fan, A Tong, X Li, X Gao, L Mei, L Zhou… - International journal …, 2015 - Taylor & Francis
Intraperitoneal chemotherapy was explored in clinical trials as a promising strategy to
improve the therapeutic effects of chemotherapy. In this work, we developed a …
improve the therapeutic effects of chemotherapy. In this work, we developed a …
Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release
LG Souza, EJ Silva, ALL Martins, MF Mota… - European journal of …, 2011 - Elsevier
Topotecan is an important cytotoxic drug that has gained broad acceptance in clinical use
for the treatment of refractory ovarian and small-cell lung cancer. The lactone active form of …
for the treatment of refractory ovarian and small-cell lung cancer. The lactone active form of …
Topotecan hydrochloride liposomes incorporated into thermosensitive hydrogel for sustained and efficient in situ therapy of H22 tumor in Kunming mice
J Xing, X Qi, Y Jiang, X Zhu, Z Zhang… - Pharmaceutical …, 2015 - Taylor & Francis
Topotecan hydrochloride (TPT) has potential for the treatment of ovarian cancer, but the
activity of TPT tends to decrease due to the ring-opening at physiological pH. In this study …
activity of TPT tends to decrease due to the ring-opening at physiological pH. In this study …
Enhancement of the fraction of the active form of an antitumor drug topotecan via an injectable hydrogel
G Chang, T Ci, L Yu, J Ding - Journal of controlled release, 2011 - Elsevier
Poly (D, L-lactic acid-co-glycolic acid)-b-poly (ethylene glycol)-b-poly (D, L-lactic acid-co-
glycolic acid)(PLGA–PEG–PLGA) hydrogels were tried as implants to encapsulate antitumor …
glycolic acid)(PLGA–PEG–PLGA) hydrogels were tried as implants to encapsulate antitumor …
Revisiting the nanoformulation design approach for effective delivery of topotecan in its stable form: an appraisal of its in vitro Behavior and tumor amelioration …
Topotecan (TPT) is indicated against a variety of solid tumors, but has restricted clinical use
owing to associated pharmaceutical caveats. This study is focused at formulating a …
owing to associated pharmaceutical caveats. This study is focused at formulating a …