Background Using interpretable machine learning, we sought to define the immune
microenvironment subtypes and distinctive genes in AD. Methods ssGSEA, LASSO …

Background The pathogenesis of Alzheimer's disease (AD) is complex and multi-factorial.
Increasing evidence has shown the important role of immune infiltration in AD. Thus the …

Introduction: Alzheimer's disease (AD) is a severe dementia with clinical and pathological
heterogeneity. Our study was aim to explore the roles of endoplasmic reticulum (ER) stress …

Background: Alzheimer's disease (AD) is the most common form of dementia in old age and
poses a severe threat to the health and life of the elderly. However, traditional diagnostic …

Objective: As a chronic neurodegenerative disorder, Alzheimer's disease (AD) is the most
common form of progressive dementia. The purpose of this study was to identify diagnostic …

Background As the most common neurodegenerative disease, Alzheimer's disease (AD)
leads to progressive loss of cognition and memory. Presently, the underlying pathogenic …

Alzheimer's disease (AD) is the most prevalent cause of dementia and is primarily
associated with memory impairment and cognitive decline, but the etiology of AD has not …

Current knowledge of Alzheimer's disease (AD) etiology and effective therapy remains
limited. Thus, the identification of biomarkers is crucial to improve the detection and …

Background Immune system dysfunction has been proven to be an important pathological
event in Alzheimer's disease (AD). Mild cognitive impairment (MCI), as a transitional stage …

Background Previous transcriptome-wide association study (TWAS) has documented 21
genes associated with Alzheimer's disease (AD) risk, but the predictive biomarkers remain …