Human age reversal: Fact or fiction?

AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …

Assessing the rate of aging to monitor aging itself

X Xia, Y Wang, Z Yu, J Chen, JDJ Han - Ageing Research Reviews, 2021 - Elsevier
Healthy aging is the prime goal of aging research and interventions. Healthy aging or not
can be quantified by biological aging rates estimated by aging clocks. Generation and …

“Epigenetic clocks”: Theory and applications in human biology

CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …

Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging

HL Porter, CA Brown, X Roopnarinesingh, CB Giles… - Aging cell, 2021 - Wiley Online Library
Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

Old and new models for the study of human ageing

A Brunet - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Human ageing is associated with high susceptibility to disease. Some aspects of ageing can
be studied directly in humans and have revealed that ageing is influenced by many factors …

Epigenetic age prediction

DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

The relationship between epigenetic age and the hallmarks of aging in human cells

S Kabacik, D Lowe, L Fransen, M Leonard, SL Ang… - Nature aging, 2022 - nature.com
Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

[HTML][HTML] Aging clocks based on accumulating stochastic variation

DH Meyer, B Schumacher - Nature Aging, 2024 - nature.com
Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …

A targeted epigenetic clock for the prediction of biological age

N Gensous, C Sala, C Pirazzini, F Ravaioli, M Milazzo… - Cells, 2022 - mdpi.com
Epigenetic clocks were initially developed to track chronological age, but accumulating
evidence indicates that they can also predict biological age. They are usually based on the …

Reversal of epigenetic aging and immunosenescent trends in humans

GM Fahy, RT Brooke, JP Watson, Z Good… - Aging cell, 2019 - Wiley Online Library
Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …