The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …

Review of the current understanding of age-dependent changes in leukocyte function and
their contribution to aging-related disease processes. Aging is associated with a progressive …

Immunosenescence is a term used to describe the age-related changes in the immune
system. Immunosenescence is associated with complex alterations and dysregulation of …

Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic
inflammatory state termed inflammaging. The significance of these phenomena is …

The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …

Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

Significance: With the growing population of baby boomers, there is a great need to
determine the effects of advanced age on the function of the immune system. Recent …

Chronic inflammation is the common pathological basis for such age-associated diseases
as cardiovascular disease, diabetes, cancer and Alzheimer's disease. A multitude of bodily …

Decreased immune responsiveness associated with aging is generally termed
“immunosenescence”. Several theories have been proposed to explain age-related declines …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …