Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem Cells
The spinal cord, nerves, and skeletal muscles arise from neuromesodermal progenitors
(NMPs). We have developed a growth-factor screening strategy, utilizing ES and iPS cells …
(NMPs). We have developed a growth-factor screening strategy, utilizing ES and iPS cells …
Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives
The anteroposterior axial identity of motor neurons (MNs) determines their functionality and
vulnerability to neurodegeneration. Thus, it is a crucial parameter in the design of strategies …
vulnerability to neurodegeneration. Thus, it is a crucial parameter in the design of strategies …
Emergence of a node-like population within an in vitro derived Neural Mesodermal Progenitors (NMPs) population
S Edri, P Hayward, W Jawaid, AM Arias - bioRxiv, 2018 - biorxiv.org
Abstract The mammalian embryos Caudal Lateral Epiblast (CLE) harbours bipotent
progenitors, called Neural Mesodermal Progenitors (NMPs), that contribute to the spinal …
progenitors, called Neural Mesodermal Progenitors (NMPs), that contribute to the spinal …
Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitro
L Verrier, L Davidson, M Gierliński, KG Storey - bioRxiv, 2017 - biorxiv.org
Robust protocols for directed differentiation of human pluripotent cells are needed to
establish the extent to which mechanisms operating in model organisms are relevant to our …
establish the extent to which mechanisms operating in model organisms are relevant to our …
Neuro-mesodermal progenitors (NMPs): a comparative study between pluripotent stem cells and embryo-derived populations
S Edri, P Hayward, W Jawaid… - Development, 2019 - journals.biologists.com
The mammalian embryo's caudal lateral epiblast (CLE) harbours bipotent progenitors,
called neural mesodermal progenitors (NMPs), that contribute to the spinal cord and the …
called neural mesodermal progenitors (NMPs), that contribute to the spinal cord and the …
Human-specific progenitor sub-domain contributes to extended neurogenesis and increased motor neuron production
S Jang, E Gunmit, H Wichterle - bioRxiv, 2022 - biorxiv.org
Neurogenesis lasts~ 10 times longer in developing humans compared to mice, resulting in>
1000-fold more neurons in the human central nervous system. Expansion of human …
1000-fold more neurons in the human central nervous system. Expansion of human …
In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity
Cells of the spinal cord and somites arise from shared, dual-fated precursors, located
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …
[PDF][PDF] Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro
F Cooper, GE Gentsch, R Mitter, C Bouissou, LE Healy… - Stem Cell Reports, 2022 - cell.com
The spinal cord emerges from a niche of neuromesodermal progenitors (NMPs) formed and
maintained by WNT/fibroblast growth factor (FGF) signals at the posterior end of the embryo …
maintained by WNT/fibroblast growth factor (FGF) signals at the posterior end of the embryo …
[PDF][PDF] Fay Cooper,* George E. Gentsch, Richard Mitter, 2 Camille Bouissou, Lyn E. Healy, 3
AH Rodriguez, JC Smith, AS Bernardo - scholar.archive.org
The spinal cord emerges from a niche of neuromesodermal progenitors (NMPs) formed and
maintained by WNT/fibroblast growth factor (FGF) signals at the posterior end of the embryo …
maintained by WNT/fibroblast growth factor (FGF) signals at the posterior end of the embryo …
Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells
Spinal motor neurons deficiency results in a series of devastating disorders such as
amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury …
amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury …