Novel genome-wide DNA methylation profiling reveals distinct epigenetic landscape, prognostic model and cellular composition of early-stage lung adenocarcinoma

J Gan, M Huang, W Wang, G Fu, M Hu, H Zhong… - Journal of Translational …, 2024 - Springer
Background Lung adenocarcinoma (LUAD) has been a leading cause of cancer-related
mortality worldwide. Early intervention can significantly improve prognosis. DNA methylation …

An integrative analysis of DNA methylation and gene expression to predict lung adenocarcinoma prognosis

L Xu, Z Huang, Z Zeng, J Li, H Xie, C Xie - Frontiers in Genetics, 2022 - frontiersin.org
Background: Abnormal DNA methylation of gene promoters is an important feature in lung
adenocarcinoma (LUAD). However, the prognostic value of DNA methylation remains to be …

Identification of a novel prognostic DNA methylation signature for lung adenocarcinoma based on consensus clustering method

Q Cai, B He, H Xie, P Zhang, X Peng, Y Zhang… - Cancer …, 2020 - Wiley Online Library
Abnormal DNA methylation persists throughout carcinogenesis and cancer development.
Hence, gene promoter methylation may act as a prognostic tool and provide new potential …

Comprehensive analysis of gene expression and DNA methylation data identifies potential biomarkers and functional epigenetic modules for lung adenocarcinoma

XC Wang, YM Li, HH Hu, FZ Zhou, J Chen… - Genetics and Molecular …, 2020 - SciELO Brasil
Lung cancer has one of the highest mortality rates of malignant neoplasms. Lung
adenocarcinoma (LUAD) is one of the most common types of lung cancer. DNA methylation …

Identification of diagnostic DNA methylation biomarkers specific for early-stage lung adenocarcinoma

Q Cai, P Zhang, B He, Z Zhao, Y Zhang, X Peng, H Xie… - Cancer Genetics, 2020 - Elsevier
Background DNA hypermethylation is a key event in oncogenesis and may act as a
biomarker for the early detection of lung adenocarcinoma (LUAD). Here, we aimed to …

A methylation-based nomogram for predicting survival in patients with lung adenocarcinoma

X Wang, B Zhou, Y Xia, J Zuo, Y Liu, X Bi, X Luo… - Bmc Cancer, 2021 - Springer
Background DNA methylation alteration is frequently observed in Lung adenocarcinoma
(LUAD) and may play important roles in carcinogenesis, diagnosis, and prognosis. Thus …

Prognostic and predictive value of three DNA methylation signatures in lung adenocarcinoma

Y Wang, H Deng, S Xin, K Zhang, R Shi, X Bao - Frontiers in genetics, 2019 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) is the leading cause of cancer-related mortality
worldwide. Molecular characterization-based methods hold great promise for improving the …

[HTML][HTML] Identification of molecular subtypes in lung adenocarcinoma based on DNA methylation and gene expression profiling—a bioinformatic analysis

S Wang, X Liang, R Guo, J Gong, X Zhong… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Molecular typing based on deoxyribonucleic acid (DNA) methylation and gene
expression can extend understandings of the molecular mechanisms involved in lung …

Integrated analysis of gene expression and DNA methylation datasets identified key genes and a 6-gene prognostic signature for primary lung adenocarcinoma

J Meng, L Cao, H Song, L Chen, Z Qu - Genetics and Molecular …, 2021 - SciELO Brasil
Lung adenocarcinoma (LUAD) is the main subtype of non-small cell lung cancer with a poor
survival prognosis. In our study, gene expression, DNA methylation, and clinicopathological …

Leveraging methylation to identify the potential causal genes associated with survival in lung adenocarcinoma and lung squamous cell carcinoma

L Liu, P Zeng, S Yang, Z Yuan - Oncology letters, 2020 - spandidos-publications.com
Understanding the different genetic landscape between lung adenocarcinoma (LUAD) and
lung squamous cell carcinoma (LUSC) is important for understanding the underlying …