The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …

Organoids are in vitro cultures of miniature fetal or adult organ-like structures. Their
potentials for use in tissue and organ replacement, disease modeling, toxicology studies …

Multicellular organisms of various complexities self-organize in nature. Organoids are in
vitro 3D structures that display important aspects of the anatomy and physiology of their in …

Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

For centuries, attempts have been continuously made to artificially reconstitute counterparts
of in vivo organs from their tissues or cells. Only in the recent decade has organoid …

During organogenesis, various molecular and physical signals are orchestrated in space
and time to sculpt multiple cell types into functional tissues and organs. The complex and …

Background Because of their differentiation potential, pluripotent stem cells can generate
virtually any cell type and, as such, can be used to model development and disease and …

Recent progress in our understanding of the regulation of epithelial tissue stem cells has
allowed us to exploit their abilities and instruct them to self-organize into tissue-mimicking …

Human adult stem cells and patient-derived induced pluripotent stem cells represent
promising tools to understand human biology, development, and disease. Under a …

Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …