Sex-and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer's disease mice

A Papazoglou, C Henseler, S Weickhardt, J Teipelke… - Plos one, 2024 - journals.plos.org
A variety of Alzheimer's disease (AD) mouse models has been established and
characterized within the last decades. To get an integrative view of the sophisticated …

[HTML][HTML] Whole genome transcriptome data from the WT cortex and hippocampus of female and male control and APP/PS1 Alzheimer's disease mice

A Papazoglou, C Henseler, S Weickhardt, J Daubner… - Data in Brief, 2023 - Elsevier
A variety of Alzheimer disease (AD) mouse models has been established and characterized
within the last decades. These models are generated to meet the principal criteria of AD …

Gene expression profiling in the APP/PS1KI mouse model of familial Alzheimer's disease

R Weissmann, M Hüttenrauch… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
early intraneuronal amyloidß (Aß) accumulation, extracellular deposition of Aß peptides, and …

Incorporating genetic diversity to improve alignment of mouse models to human Alzheimer's disease

A Uyar, D Garceau, D Bednarczyk… - Alzheimer's & …, 2021 - Wiley Online Library
Background Previous work by our labs, and others, reveal the benefits of incorporating
diverse mouse strains to better model human Alzheimer's disease (AD). For instance, mouse …

Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression

L Soreq, H Bird, W Mohamed, J Hardy - Plos one, 2023 - journals.plos.org
Alzheimer's disease is the most common neurological disease worldwide. Unfortunately,
there are currently no effective treatment methods nor early detection methods. Furthermore …

Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer's disease

A Onisiforou, CC Christodoulou… - Frontiers in …, 2024 - frontiersin.org
Background The hippocampus, vital for memory and learning, is among the first brain
regions affected in Alzheimer's Disease (AD) and exhibits adult neurogenesis. Women face …

Sex specific molecular networks and key drivers of Alzheimer's disease

L Guo, J Cao, J Hou, Y Li, M Huang, L Zhu… - Molecular …, 2023 - Springer
Background Alzheimer's disease (AD) is a progressive and age-associated
neurodegenerative disorder that affects women disproportionally. However, the underlying …

Aging related transcriptomic changes in the mouse models of alzheimer's disease

A Uyar, R Pandey, C Preuss, K Kotredes… - Innovation in …, 2020 - ncbi.nlm.nih.gov
Alzheimer's Disease (AD) is characterized by multiple clinical phenotypes and molecular
signatures at different stages of the disease and aging is the major risk factor for sporadic …

Big data analysis of genes associated with neuropsychiatric disorders in an Alzheimer's disease animal model

S Ham, TK Kim, H Hong, YS Kim, YP Tang… - Frontiers in …, 2018 - frontiersin.org
Alzheimer's disease is a neurodegenerative disease characterized by the impairment of
cognitive function and loss of memory, affecting millions of individuals worldwide. With the …

[HTML][HTML] CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal-and synapse-related gene expression in APP-PS1 transgenic mice

MS Unger, E Li, L Scharnagl, R Poupardin… - Brain, Behavior, and …, 2020 - Elsevier
Neuroinflammation is a major contributor to disease progression in Alzheimer's disease
(AD) and is characterized by the activity of brain resident glial cells, in particular microglia …