[HTML][HTML] Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma
K Hu, Z Xu, L Yao, Y Yan, L Zhou, J Li - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Six Gasdermins (GSDM) family members participate in various biological processes
especially pyroptosis, as well as in the initiation and development of many types of cancer …
especially pyroptosis, as well as in the initiation and development of many types of cancer …
[HTML][HTML] Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma
J Wei, Z Xu, X Chen, X Wang… - Molecular …, 2020 - spandidos-publications.com
The gasdermin (GSDM) superfamily has been demonstrated to consist of several important
molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this …
molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this …
A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins
M Mu, Q Yu, Q Zhang, J Guo, X Wang, X Sun… - Cancer Cell …, 2022 - Springer
Abstract Background The gasdermins (GSDMs) family is proposed to be pore-forming
effector proteins that cause cell membrane permeabilization and pyroptosis. Despite our …
effector proteins that cause cell membrane permeabilization and pyroptosis. Despite our …
[HTML][HTML] Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma
LS Peng, SL Duan, RQ Li, D Wang, YY Han… - Frontiers in …, 2022 - frontiersin.org
Background: The GSDM family includes six members, GSDMA, GSDMB, GSDMC, GSDMD,
GSDME (DFNA5), and PJVK (Pejvakin, DFNB59), which can induce pyroptosis, thereby …
GSDME (DFNA5), and PJVK (Pejvakin, DFNB59), which can induce pyroptosis, thereby …
[HTML][HTML] Prognostic and immunological role of gasdermin E in pan-cancer analysis
Z Zhang, S Zhao, H Yang, Y Chen, H Feng, M An… - Frontiers in …, 2021 - frontiersin.org
Despite accumulating cell-or animal-based experiments providing the relationship between
Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan …
Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan …
[HTML][HTML] Biological functions of gasdermins in cancer: from molecular mechanisms to therapeutic potential
M Wang, X Chen, Y Zhang - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Pyroptosis is a type of lytic programmed cell death triggered by various inflammasomes that
sense danger signals. Pyroptosis has recently attracted great attention owing to its …
sense danger signals. Pyroptosis has recently attracted great attention owing to its …
Upregulated GSDMB in clear cell renal cell carcinoma is associated with immune infiltrates and poor prognosis
Y Cui, Z Zhou, Y Chai, Y Zhang - Journal of immunology …, 2021 - Wiley Online Library
Gasdermin B (GSDMB) is part of the gasdermin (GSDM) family, and they use varying means
of domain interactions in molecules to adjust their pore‐forming and lipid‐binding actions …
of domain interactions in molecules to adjust their pore‐forming and lipid‐binding actions …
Gasdermin D is a novel prognostic biomarker and relates to TMZ response in glioblastoma
J Liu, L Gao, X Zhu, R Geng, X Tao, H Xu, Z Chen - Cancers, 2021 - mdpi.com
Simple Summary GSMD family were crucial regulators of pyroptosis. We used WB, IHC and
bioinformatics to explore expression and potential role of GSDMs family in the progression …
bioinformatics to explore expression and potential role of GSDMs family in the progression …
A systematic pan-cancer analysis of the gasdermin (GSDM) family of genes and their correlation with prognosis, the tumor microenvironment, and drug sensitivity
Y Zheng, D Yuan, F Zhang, R Tang - Frontiers in Genetics, 2022 - frontiersin.org
Background: Pyroptosis is a programmed cell death process mediated by the gasdermin
(GSDM) protein. However, limited research has been conducted to comprehensively …
(GSDM) protein. However, limited research has been conducted to comprehensively …
Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good …
J Gao, X Qiu, G Xi, H Liu, F Zhang… - Oncology …, 2018 - spandidos-publications.com
Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be
cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical …
cleaved by inflammatory caspases and is essential for secretion of IL‑1β, making it a critical …