Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry

Y Shao, T Li, Z Liu, X Wang, X Xu, S Li, G Xu… - Molecular …, 2021 - Springer
Background Parkinson's disease (PD) is a prevalent neurological disease in the elderly with
increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis …

Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease

Y Shao, W Le - Molecular neurodegeneration, 2019 - Springer
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

T Hatano, S Saiki, A Okuzumi, RP Mohney… - Journal of Neurology …, 2016 - jnnp.bmj.com
Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions
between environmental and genetic factors. Metabolomics can shed light on alterations in …

Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study

JR Roede, K Uppal, Y Park, K Lee, V Tran, D Walker… - PloS one, 2013 - journals.plos.org
Progression of Parkinson's disease (PD) is highly variable, indicating that differences
between slow and rapid progression forms could provide valuable information for improved …

Promising metabolite profiles in the plasma and CSF of early clinical Parkinson's disease

D Stoessel, C Schulte… - Frontiers in aging …, 2018 - frontiersin.org
Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular
pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging …

Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson's disease reveals distinct metabolic profiles

SF Graham, NL Rey, A Yilmaz, P Kumar… - Journal of proteome …, 2018 - ACS Publications
Parkinson's disease is the second most common neurodegenerative disease. In the vast
majority of cases the origin is not genetic and the cause is not well understood, although …

Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling

H Zhao, C Wang, N Zhao, W Li, Z Yang, X Liu… - … of Chromatography B, 2018 - Elsevier
The plasma of Parkinson's disease (PD) patients may contain various altered metabolites
associated with the risk or progression of the disease. Characterization of the abnormal …

Prognostic biomarkers of Parkinson's disease in the Spanish EPIC cohort: A multiplatform metabolomics approach

C Gonzalez-Riano, J Saiz, C Barbas… - npj Parkinson's …, 2021 - nature.com
The lack of knowledge about the onset and progression of Parkinson's disease (PD)
hampers its early diagnosis and treatment. Metabolomics might shed light on the PD imprint …

Biomarker research in Parkinson's disease using metabolite profiling

JF Havelund, NHH Heegaard, NJK Færgeman… - Metabolites, 2017 - mdpi.com
Biomarker research in Parkinson's disease (PD) has long been dominated by measuring
dopamine metabolites or alpha-synuclein in cerebrospinal fluid. However, these markers do …

Integrated metabolomics and proteomics analysis reveals plasma lipid metabolic disturbance in patients with Parkinson's disease

L Hu, MX Dong, YL Huang, CQ Lu, Q Qian… - Frontiers in Molecular …, 2020 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease in the elderly with a
pathogenesis that remains unclear. We aimed to explore its pathogenesis through plasma …