An era of single-cell genomics consortia
The human body consists of 37 trillion single cells represented by over 50 organs that are
stitched together to make us who we are, yet we still have very little understanding about the …
stitched together to make us who we are, yet we still have very little understanding about the …
The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans
SR Quake - 2021 - europepmc.org
Molecular characterization of cell types using single cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs …
revolutionizing cell biology and enabling new insights into the physiology of human organs …
Single-cell genomics technology: perspectives
In the last decade, molecular and cellular technologies have evolved to give rise to the era
of single-cell genomics, which allows the simultaneous measurement of thousands of genes …
of single-cell genomics, which allows the simultaneous measurement of thousands of genes …
The Tabula Sapiens: a single cell transcriptomic atlas of multiple organs from individual human donors
Tabula Sapiens Consortium, SR Quake - Biorxiv, 2021 - biorxiv.org
In recent years there has been tremendous progress towards deep molecular
characterization of cell types using single cell transcriptome sequencing. Here we report a …
characterization of cell types using single cell transcriptome sequencing. Here we report a …
Lack of ethnic diversity in single-cell transcriptomics hinders cell type detection and precision medicine inclusivity
Perhaps one of the most revolutionary next generation sequencing technologies is single-
cell (SC) transcriptomics, which was recognized by Nature in 2013 as the method of the …
cell (SC) transcriptomics, which was recognized by Nature in 2013 as the method of the …
Mapping human cell phenotypes to genotypes with single-cell genomics
JG Camp, R Platt, B Treutlein - Science, 2019 - science.org
The cumulative activity of all of the body's cells, with their myriad interactions, life histories,
and environmental experiences, gives rise to a condition that is distinctly human and specific …
and environmental experiences, gives rise to a condition that is distinctly human and specific …
Single-cell analysis: toward the clinic
MR Speicher - Genome medicine, 2013 - Springer
© 2013 BioMed Central Ltd muscle, and normal tissue in the proximity of tumors [4]. If this
material were obtained in a viable form, somatic cells could be reprogrammed in order to …
material were obtained in a viable form, somatic cells could be reprogrammed in order to …
Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
Background As core units of organ tissues, cells of various types play their harmonious
rhythms to maintain the homeostasis of the human body. It is essential to identify the …
rhythms to maintain the homeostasis of the human body. It is essential to identify the …
DISCO: a database of Deeply Integrated human Single-Cell Omics data
The ability to study cellular heterogeneity at single cell resolution is making single-cell
sequencing increasingly popular. However, there is no publicly available resource that …
sequencing increasingly popular. However, there is no publicly available resource that …
Challenges and emerging directions in single-cell analysis
Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular
information at the individual cell level. Development of single-cell technologies and …
information at the individual cell level. Development of single-cell technologies and …