Early life adversity (ELA) tends to accelerate neurobiological ageing, which, in turn, is
thought to heighten vulnerability to both major depressive disorder (MDD) and Alzheimer's …

In adulthood, stress exposure and genetic risk heighten psychological vulnerability by
accelerating neurobiological senescence. To investigate whether molecular and brain …

Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Early life stress (ELS), such as abuse, neglect, and maltreatment, is a well-known risk factor
for mental illness. However, it is unclear how ELS affects the brain and cognitive …

Background Different types of early-life adversity have been associated with children's brain
structure and function. However, understanding the disparate influence of distinct adversity …

Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Critical environmental factors like physical threats, air pollution, and infections, alongside
social determinants of health (SDH)(Ibáñez et al., 2023) such as social disparities …

Background Genetics play a significant role in the etiology of late-life neurodegenerative
diseases like Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. Part …

Background Genome-wide association studies demonstrate that Alzheimer's disease (AD)
has a highly polygenic architecture, where thousands of independent genetic variants …

Most patients with late-onset neurodegenerative diseases such as Alzheimer's and
Parkinson's have a complex aetiology resulting from numerous genetic risk variants of small …