In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Cardiac excitation–contraction coupling occurs primarily at the sites of transverse (T)-
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

T‐tubules are invaginations of the cardiomyocyte membrane into the cell interior which form
a tortuous network. T‐tubules provide proximity between the electrically excitable cell …

Aims Chronic heart failure is a complex clinical syndrome with impaired myocardial
contractility. In failing cardiomyocytes, decreased signalling efficiency between the L-type …

A characteristic histological feature of striated muscle cells is the presence of deep
invaginations of the plasma membrane (sarcolemma), most commonly referred to as T …

The transverse tubules (t-tubules) are invaginations of the cell membrane rich in several ion
channels and other proteins devoted to the critical task of excitation–contraction coupling in …

Although the existence of t-tubules in mammalian cardiac ventricular myocytes has been
recognized for a long time, it now appears that their structure and function are more complex …

Abstract Purpose of Review Membrane invaginations called t-tubules play an integral role in
triggering cardiomyocyte contraction, and their disruption during diseases such as heart …

Action potential–driven Ca2+ currents from the transverse tubules (t-tubules) trigger
synchronous Ca2+ release from the sarcoplasmic reticulum of cardiomyocytes. Loss of t …