[PDF][PDF] Genome scans of diverse dog behaviors implicate a neurodevelopmental gene network in mammalian adaptation and psychopathology

Genetic studies show a general factor associated with all human personality and
psychopathology, but its basis is unknown. We performed genome scans of 17 normal and …

Genome scans of dog behavior implicate a gene network underlying psychopathology in mammals, including humans

I Zapata, EE Hecht, JA Serpell, CE Alvarez - BioRxiv, 2020 - biorxiv.org
Genetic studies show a general factor associated with all human psychopathology and
strongly correlated with personality and intelligence, but its basis is unknown. We performed …

The Genomics of Canine Behavior and its Comparative Relevance to Human Neuropsychiatric Conditions

K Morrill - 2023 - repository.escholarship.umassmed …
Mounting genomic evidence suggests that biological contributions to psychiatric disorder
susceptibility are genetically complex, environmentally mediated, and highly comorbid. By …

Genetic testing of dogs predicts problem behaviors in clinical and nonclinical samples

I Zapata, ML Lilly, ME Herron, JA Serpell, CE Alvarez - BMC genomics, 2022 - Springer
Background Very little is known about the etiology of personality and psychiatric disorders.
Because the core neurobiology of many such traits is evolutionarily conserved, dogs present …

Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics

K Morrill, F Chen, E Karlsson - Human Genetics, 2023 - Springer
Domestic dogs display a wide array of heritable behaviors that have intermediate genetic
complexity thanks to a long history of human-influenced selection. Comparative genetics in …

Highly heritable and functionally relevant breed differences in dog behaviour

EL MacLean, N Snyder-Mackler… - … of the Royal …, 2019 - royalsocietypublishing.org
Variation across dog breeds presents a unique opportunity to investigate the evolution and
biological basis of complex behavioural traits. We integrated behavioural data from more …

Analysis of the canine brain transcriptome with an emphasis on the hypothalamus and cerebral cortex

M Roy, N Kim, K Kim, WH Chung… - Mammalian …, 2013 - Springer
The diversity of dog breeds make the domestic dog a valuable model for identifying genes
responsible for many phenotypic and behavioral traits. The brain, in particular, is a region of …

The critical importance of basic animal research for neuropsychiatric disorders

TL Bale, T Abel, H Akil, WA Carlezon Jr… - …, 2019 - nature.com
The challenges and critical importance of keeping our thinking about neuropsychiatric
disorders mechanisms and classifications up-to-date have prompted a dynamic discourse …

How the dog got its spots

GS Barsh - Nature Genetics, 2007 - nature.com
Differences among dog breeds provide unique opportunities for studying the genetics of
behavior, morphology and complex disease. Two new studies demonstrate how the unique …

Genetic dissection of complex behaviour traits in German Shepherd dogs

J Friedrich, E Strandberg, P Arvelius… - Heredity, 2019 - nature.com
A favourable genetic structure and diversity of behavioural features highlights the potential
of dogs for studying the genetic architecture of behaviour traits. However, behaviours are …