Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

The accumulation of stochastic DNA damage throughout an organism's lifespan is thought to
contribute to ageing. Conversely, ageing seems to be phenotypically reproducible and …

DNA damage contributes to cancer development and aging. Congenital syndromes that
affect DNA repair processes are characterized by cancer susceptibility, developmental …

Of all the proposed causes of ageing, DNA damage remains a leading, though still debated
theory. Unlike most other types of age-related cellular damage, which can hypothetically be …

Background Mammalian aging is a highly complex process, a full mechanistic
understanding of which is still lacking. One way to help understand the molecular changes …

Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …

Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of
defense have evolved to reduce the accumulation of DNA damage, including reducing …