Evidence for embracing normative modeling

S Rutherford, P Barkema, IF Tso, C Sripada… - Elife, 2023 - elifesciences.org
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …

The burden of reliability: How measurement noise limits brain-behaviour predictions

M Gell, SB Eickhoff, A Omidvarnia, V Küppers, KR Patil… - BioRxiv, 2023 - biorxiv.org
Current major efforts in human neuroimaging research aim to understand individual
differences and identify biomarkers for clinical applications. One particularly promising …

Brain–phenotype models fail for individuals who defy sample stereotypes

AS Greene, X Shen, S Noble, C Horien, CA Hahn… - Nature, 2022 - nature.com
Individual differences in brain functional organization track a range of traits, symptoms and
behaviours,,,,,,,,,,–. So far, work modelling linear brain–phenotype relationships has …

Suboptimal phenotypic reliability impedes reproducible human neuroscience

A Nikolaidis, AA Chen, X He, R Shinohara… - BioRxiv, 2022 - biorxiv.org
Paragraph Biomarkers of behavior and psychiatric illness for cognitive and clinical
neuroscience remain out of reach–. Suboptimal reliability of biological measurements, such …

Population heterogeneity in clinical cohorts affects the predictive accuracy of brain imaging

O Benkarim, C Paquola, B Park, V Kebets, SJ Hong… - PLoS …, 2022 - journals.plos.org
Brain imaging research enjoys increasing adoption of supervised machine learning for
single-participant disease classification. Yet, the success of these algorithms likely depends …

The normative modeling framework for computational psychiatry

S Rutherford, SM Kia, T Wolfers, C Fraza, M Zabihi… - Nature protocols, 2022 - nature.com
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …

Beyond accuracy: Measures for assessing machine learning models, pitfalls and guidelines

R Dinga, BWJH Penninx, DJ Veltman, L Schmaal… - BioRxiv, 2019 - biorxiv.org
Pattern recognition predictive models have become an important tool for analysis of
neuroimaging data and answering important questions from clinical and cognitive …

Cross-ethnicity/race generalization failure of behavioral prediction from resting-state functional connectivity

J Li, D Bzdok, J Chen, A Tam, LQR Ooi, AJ Holmes… - Science …, 2022 - science.org
Algorithmic biases that favor majority populations pose a key challenge to the application of
machine learning for precision medicine. Here, we assessed such bias in prediction models …

Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression

SM Kia, H Huijsdens, S Rutherford, A de Boer, R Dinga… - Plos one, 2022 - journals.plos.org
Clinical neuroimaging data availability has grown substantially in the last decade, providing
the potential for studying heterogeneity in clinical cohorts on a previously unprecedented …

Deriving reproducible biomarkers from multi-site resting-state data: An Autism-based example

A Abraham, MP Milham, A Di Martino, RC Craddock… - NeuroImage, 2017 - Elsevier
Abstract Resting-state functional Magnetic Resonance Imaging (R-fMRI) holds the promise
to reveal functional biomarkers of neuropsychiatric disorders. However, extracting such …