[HTML][HTML] Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway
YL Wang, JG Wang, S Guo, FL Guo, EJ Liu… - Aging and …, 2023 - ncbi.nlm.nih.gov
Neuronal synchronization at gamma frequency (30-100 Hz: γ) is impaired in early-stage
Alzheimer's disease (AD) patients and AD models. Oligomeric Aβ 1-42 caused a …
Alzheimer's disease (AD) patients and AD models. Oligomeric Aβ 1-42 caused a …
Optogenetic activation of SST-positive interneurons restores hippocampal theta oscillation impairment induced by soluble amyloid beta oligomers in vivo
Abnormal accumulation of amyloid β oligomers (AβO) is a hallmark of Alzheimer's disease
(AD), which leads to learning and memory deficits. Hippocampal theta oscillations that are …
(AD), which leads to learning and memory deficits. Hippocampal theta oscillations that are …
[HTML][HTML] Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β …
Accumulation of amyloid β oligomers (AβO) in Alzheimer's disease (AD) impairs
hippocampal theta and gamma oscillations. These oscillations are important in memory …
hippocampal theta and gamma oscillations. These oscillations are important in memory …
[HTML][HTML] Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike …
Background Abnormal accumulation of amyloid β 1–42 oligomers (AβO 1–42), a hallmark of
Alzheimer's disease, impairs hippocampal theta-nested gamma oscillations and long-term …
Alzheimer's disease, impairs hippocampal theta-nested gamma oscillations and long-term …
[HTML][HTML] Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer's disease
H Zhou, H Li, N Gowravaram, M Quan, N Kausar… - Scientific Reports, 2022 - nature.com
The Alzheimer's disease-associated peptide amyloid-beta (Aβ) has been associated with
neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural …
neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural …
Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice
Amyloid-β (Aβ) peptide overproduction is one of the pathomechanisms contributing to
Alzheimer's disease (AD). Agonists of α7 nicotinic acetylcholine receptors (α7 nAChRs) are …
Alzheimer's disease (AD). Agonists of α7 nicotinic acetylcholine receptors (α7 nAChRs) are …
S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS
The pro-inflammatory and highly amyloidogenic protein S100A9 is central to the amyloid-
neuroinflammatory cascade in neurodegenerative diseases leading to cognitive impairment …
neuroinflammatory cascade in neurodegenerative diseases leading to cognitive impairment …
Alterations in hippocampal network oscillations and theta–gamma coupling arise before Aβ overproduction in a mouse model of A lzheimer's disease
R Goutagny, N Gu, C Cavanagh… - European Journal of …, 2013 - Wiley Online Library
Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterized by
memory impairments. Brain oscillatory activity is critical for cognitive function and is altered …
memory impairments. Brain oscillatory activity is critical for cognitive function and is altered …
Theta and gamma oscillatory dynamics in mouse models of Alzheimer's disease: A path to prospective therapeutic intervention
SF Mehak, AB Shivakumar, S Kumari… - Neuroscience & …, 2022 - Elsevier
Understanding the neural basis of cognitive deficits, a key feature of Alzheimer's disease
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …
[HTML][HTML] p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease
AA Ittner, A Gladbach, J Bertz, LS Suh… - Acta Neuropathologica …, 2014 - Springer
Hypersynchronicity of neuronal brain circuits is a feature of Alzheimer's disease (AD). Mouse
models of AD expressing mutated forms of the amyloid-β precursor protein (APP), a central …
models of AD expressing mutated forms of the amyloid-β precursor protein (APP), a central …