Background Considerable evidence indicates that a signaling crosstalk between the brain
and periphery plays important roles in neurological disorders, and that both acute and …

Aims Exposure to crystalline silica (CS) in occupational settings induces chronic
inflammation in the respiratory system and, potentially, the brain. Some workers are …

Abstract Background Silica nanoparticles (SiO 2-NPs) are naturally enriched and broadly
utilized in the manufacturing industry. While previous studies have demonstrated toxicity in …

Increasing environmental exposure to silica nanoparticles (SiNPs) and limited neurotoxicity
studies pose a challenge for safety evaluation and management of these materials. This …

Introduction Silica nanoparticles (SiO2-NPs) are currently among the most widely used
nanomaterials, but their potentially adverse effects on brain development remain unknown …

Autophagy is an important metabolic mechanism that can promote cellular survival following
injury. The specific contribution of autophagy to silica-induced inflammation and disease is …

Air pollution is implicated in neurodegenerative disease risk and progression and in
microglial activation, but the mechanisms are unknown. In this study, microglia remained …

Long‐term exposure to respirable silica particles causes pulmonary inflammation and
fibrosis primarily promoted by cytokines released from alveolar macrophages, yet the …

Background Silica nanoparticles (SiNPs) are being formulated for cellular imaging and for
nonviral gene delivery in the central nervous system (CNS), but it is unclear what potential …

Silica nanoparticles (SiO2-NPs) are being used increasingly in diagnosis, imaging, and drug
delivery for the central nervous system. However, to date, little is known concerning the …