The failure to generate enduring humoral immunity after vaccination is a hallmark of
advancing age. This can be attributed in part to a reduction in the germinal center response …

The failure to generate enduring humoral immunity after vaccination is a hallmark of
advancing age. This can be attributed to a reduction in the germinal center (GC) response …

Adults over 65 years of age are more vulnerable to infectious disease and show poor
responses to vaccination relative to those under 50. A complex set of age-related changes in …

Aging negatively impacts immunity, resulting in inefficient responses to vaccinations and
infections. Fibroblastic reticular cells (FRCs) are the major stromal cell subset in lymph …

The decreased proportion of antigen-inexperienced, naïve T cells is a hallmark of aging in
both humans and mice, and contributes to reduced immune responses, particularly against …

Aging is characterized by progressive loss of organ and tissue function, and the immune
system is no exception to that inevitable principle. Of all the age-related changes in the …

Declining immune function with age is associated with reduced lymphoid output of
hematopoietic stem cells (HSCs). Currently, there is poor understanding of changes with …

The generation of high-affinity long-lived antibody responses is dependent on the
differentiation of plasma cells and memory B cells, which are themselves the product of the …

Highlights•Immune function declines with age.•Extrinsic factors contribute towards
immunosenescence.•Aged stromal niche offers a potential target for therapy.The major …

The secondary lymphoid organs (SLOs) undergo structural changes with age, which
correlates with diminishing immune responses against infectious disease. A growing body of …