Aging results in profound immune dysfunction, resulting in the decline of vaccine
responsiveness previously attributed to irreversible defects in the immune system. In …

Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in
response to vaccination, producing long-lived antibody secreting plasma cells and memory …

We and others have shown that regulatory T cells (Treg) accumulate dramatically with age in
both humans and mice. Such Treg accrual contributes to age-related immunosenescence as …

T follicular helper (TFH) cell responses are essential for generation of protective humoral
immunity during influenza infection. Aging has a profound impact on CD4+ T cell function …

Defective antibody production in aging is broadly attributed to immunosenescence.
However, the precise immunological mechanisms remain unclear. Here, we demonstrate an …

Decline in immune function and inflammation concomitantly develop with ageing. Here we
focus on the impact of this inflammatory environment on T cells, and demonstrate that in …

Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic
inflammatory state termed inflammaging. The significance of these phenomena is …

Immunosenescence influences many components of the immune system. Most importantly,
profound changes in T cell function are evident in older individuals. The impact of aging on …

Alterations in immunity that occur with aging likely contribute to the development of infection,
malignancy and inflammatory diseases. Naturally occurring CD4+ regulatory T cells (Treg) …

Impaired vaccine responses in older individuals are associated with alterations in both the
quantity and quality of the T-cell compartment with age. As reviewed herein, the T-cell …