Early life stress is associated with earlier emergence of permanent molars
CL McDermott, K Hilton, AT Park… - Proceedings of the …, 2021 - National Acad Sciences
Exposure to adversity can accelerate biological aging. However, existing biomarkers of early
aging are either costly and difficult to collect, like epigenetic signatures, or cannot be …
aging are either costly and difficult to collect, like epigenetic signatures, or cannot be …
Differences in childhood stress between Neanderthals and early modern humans as reflected by dental enamel growth disruptions
Neanderthals' lives were historically portrayed as highly stressful, shaped by constant
pressures to survive in harsh ecological conditions, thus potentially contributing to their …
pressures to survive in harsh ecological conditions, thus potentially contributing to their …
Teeth as potential new tools to measure early-life adversity and subsequent mental health risk: an interdisciplinary review and conceptual model
Early-life adversity affects nearly half of all youths in the United States and is a known risk
factor for psychiatric disorders across the life course. One strategy to prevent mental illness …
factor for psychiatric disorders across the life course. One strategy to prevent mental illness …
Uncovering system-specific stress signatures in primate teeth with multimodal imaging
Early life stress can disrupt development and negatively impact long-term health trajectories.
Reconstructing histories of early life exposure to external stressors is hampered by the …
Reconstructing histories of early life exposure to external stressors is hampered by the …
Analysis of socioeconomic disadvantage and pace of aging measured in saliva DNA methylation of children and adolescents
Children who grow up in socioeconomically disadvantaged families face increased burden
of disease and disability as they mature into adulthood. One hypothesized mechanism for …
of disease and disability as they mature into adulthood. One hypothesized mechanism for …
Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents
Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …
development, which may contribute to poor mental and physical health outcomes. Evidence …
Early adversities accelerate epigenetic aging into adulthood: a 10‐year, within‐subject analysis
WE Copeland, L Shanahan… - Journal of Child …, 2022 - Wiley Online Library
Background Longitudinal studies are needed to clarify whether early adversities are
associated with advanced methylation age or if they actually accelerate methylation aging …
associated with advanced methylation age or if they actually accelerate methylation aging …
Intra-individual methylomics detects the impact of early-life adversity
Genetic and environmental factors interact during sensitive periods early in life to influence
mental health and disease via epigenetic processes such as DNA methylation. However, it …
mental health and disease via epigenetic processes such as DNA methylation. However, it …
Exposure to violence accelerates epigenetic aging in children
Epigenetic processes, including DNA methylation, change reliably with age across the
lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic …
lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic …
Extremely low birth weight and accelerated biological aging
METHODS: Buccal cells were collected from 45 ELBW survivors and 49 NBW control
participants at 30 to 35 years of age. Epigenetic age was calculated from the weighted …
participants at 30 to 35 years of age. Epigenetic age was calculated from the weighted …