Cell death is an important part of the life cycle, serving as a foundation for both the orderly
development and the maintenance of physiological equilibrium within organisms. This …

Programmed cell death is pivotal for several physiological processes, including immune
defense. Further, it has been implicated in the pathogenesis of developmental disorders and …

Disulfidptosis is a novel form of cell death that is distinguishable from established
programmed cell death pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and …

A recent study published in Nature Cell Biology demonstrated a novel type of regulated cell
death (RCD) termed disulfidptosis that is caused by excessive disulfide formation in actin …

Disulfidptosis occurs as a result of the accumulation of intracellular cystine followed by
disulfide stress in actin cytoskeleton proteins due to a reduction of NADPH produced …

The mystery about the mechanistic basis of disulfidptosis has recently been unraveled and
shows promise as an effective treatment modality for triggering cancer cell death. However …

Cell death is a fundamental physiological process that occurs in all organisms and is crucial
to each organism's evolution, ability to maintain a stable internal environment, and the …

Disulfidptosis: Disulfide Stress Mediates a Novel Cell Death Pathway via Actin Cytoskeletal
Vulnerability - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Excessive accumulation of disulfide molecules, like cystine, can induce disulfide stress and
high toxicity in cells, but the reduced form of nicotinamide adenine dinucleotide phosphate …

To get a systematic assessment of disulfidptosis-related genes across human cancers and
explore the predictive role of disulfidptosis in cancer drug sensitivity. We developed a score …