Cancer therapeutics are often highly toxic to the patient, and they often elicit rapid resistance
in the tumour. Recent advances have suggested a potential new way in which we may …

During development and throughout adult life, sub-populations of cells exist that exhibit
phenotypic plasticity–the ability to differentiate into multiple lineages. This behaviour is …

Overcoming resistance to standard anticancer treatments represents a significant challenge.
The interest regarding cancer stem cells, a cellular population that has the ability to self …

The existence of cancer cells with stem cell properties (Cancer Stem Cells, CSCs) and their
association with tumor resistance and relapse has led to the search for active compounds to …

Human tumour growth can typically be studied only during the last quarter of its
development after the tumour has been detected and in the presence of therapeutic …

Cancer comprises heterogeneous cells, ranging from highly proliferative immature
precursors to more differentiated cell lineages. The emergence of the “cancer stem …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

The main challenges in developing effective anti-cancer therapies stem from the highly
complex and heterogeneous nature of cancer, including the presence of multiple genetically …

Cancer development is widely recognized to be a somatic cell evolutionary process with
complex dynamics and highly variable time frames. Variant cells and descendent subclones …

All multicellular organisms require a continuous homeostatic control of cellular proliferation
and differentiation in order to maintain the numbers of the different types of cells and the …