[HTML][HTML] Development of epigenetic clocks for key ruminant species

A Caulton, KG Dodds, KM McRae, C Couldrey… - Genes, 2021 - mdpi.com
Robust biomarkers of chronological age have been developed in humans and model
mammalian species such as rats and mice using DNA methylation data. The concept of …

DNA methylation clocks for dogs and humans

S Horvath, AT Lu, A Haghani… - Proceedings of the …, 2022 - National Acad Sciences
DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …

[HTML][HTML] An epigenetic aging clock for cattle using portable sequencing technology

BJ Hayes, LT Nguyen, M Forutan, BN Engle… - Frontiers in …, 2021 - frontiersin.org
Extensively grazed cattle are often mustered only once a year. Therefore, birthdates are
typically unknown or inaccurate. Birthdates would be useful for deriving important traits …

MammalMethylClock R package: software for DNA methylation-based epigenetic clocks in mammals

J Zoller, S Horvath - Bioinformatics, 2024 - academic.oup.com
Motivation Epigenetic clocks are prediction methods based on DNA methylation levels in a
given species or set of species. Defined as multivariate regression models, these DNA …

[HTML][HTML] Epigenetic clock and methylation studies in cats

K Raj, B Szladovits, A Haghani, JA Zoller, CZ Li… - GeroScience, 2021 - Springer
Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …

[HTML][HTML] Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity

KM Schachtschneider, LB Schook, JJ Meudt… - GeroScience, 2021 - Springer
DNA-methylation profiles have been used successfully to develop highly accurate
biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array …

DNA methylation markers of age (ing) in non‐model animals

M Tangili, AJ Slettenhaar, J Sudyka… - Molecular …, 2023 - Wiley Online Library
Inferring the chronological and biological age of individuals is fundamental to population
ecology and our understanding of ageing itself, its evolution, and the biological processes …

[HTML][HTML] Epigenetic clock and methylation studies in vervet monkeys

AJ Jasinska, A Haghani, JA Zoller, CZ Li, A Arneson… - GeroScience, 2022 - Springer
DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …

Epigenetic aging in cows is accelerated by milk production

P Ratan, L Rubbi, M Thompson, K Naresh, J Waddell… - Epigenetics, 2023 - Taylor & Francis
ABSTRACT DNA methylation has proven to be the most promising age-predictive biomarker
in mammals resulting in the emergence of 'epigenetic clocks' that describe the relationship …

Epigenetic clock and methylation studies in elephants

NA Prado, JL Brown, JA Zoller, A Haghani, M Yao… - Aging cell, 2021 - Wiley Online Library
Age‐associated DNA‐methylation profiles have been used successfully to develop highly
accurate biomarkers of age (" epigenetic clocks") in humans, mice, dogs, and other species …