CD155 and its receptors in cancer immune escape and immunotherapy

R Zhou, S Chen, Q Wu, L Liu, Y Wang, Y Mo, Z Zeng… - Cancer letters, 2023 - Elsevier
In recent years, there have been multiple breakthroughs in cancer immunotherapy, with
immune checkpoint inhibitors becoming the most promising treatment strategy. However …

Tumor intrinsic and extrinsic immune functions of CD155

JS O'Donnell, J Madore, XY Li, MJ Smyth - Seminars in cancer biology, 2020 - Elsevier
Abstract CD155 (PVR/necl5/Tage4), a member of the nectin-like family of adhesion
molecules, is highly upregulated on tumor cells across multiple cancer types and has been …

[HTML][HTML] CD155/TIGIT, a novel immune checkpoint in human cancers

L Liu, X You, S Han, Y Sun, J Zhang… - Oncology …, 2021 - spandidos-publications.com
CD155/T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a novel type of immune
checkpoint. CD155 is an adhesion molecule that is upregulated during tumor progression …

[HTML][HTML] CD155 and its receptors as targets for cancer therapy

R Paolini, R Molfetta - International Journal of Molecular Sciences, 2023 - mdpi.com
CD155, also known as the poliovirus receptor, is an adhesion molecule often overexpressed
in tumors of different origins where it promotes cell migration and proliferation. In addition to …

[HTML][HTML] Role of CD155/TIGIT in digestive cancers: promising cancer target for immunotherapy

D Wang, Y Gu, X Yan, C Huo, G Wang, Y Zhao… - Frontiers in …, 2022 - frontiersin.org
The tumor microenvironment restricts the function and survival of various immune cells by up-
regulating inhibitory immune checkpoints, and participates in the immune escape of tumors …

CD155: a key receptor playing diversified roles

SS Nandi, T Gohil, SA Sawant… - Current Molecular …, 2022 - ingentaconnect.com
Cluster of differentiation (CD155), formerly identified as poliovirus receptor (PVR) and later
as immunoglobulin molecule, is involved in cell adhesion, proliferation, invasion and …

[HTML][HTML] CD155: A multi-functional molecule in tumor progression

R Molfetta, B Zitti, M Lecce, ND Milito, H Stabile… - International journal of …, 2020 - mdpi.com
CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often
overexpressed on tumor cells and involved in many different processes such as cell …

CD155 in tumor progression and targeted therapy

M Zhan, Z Zhang, X Zhao, Y Zhang, T Liu, L Lu, XY Li - Cancer Letters, 2022 - Elsevier
CD155, also known as the poliovirus receptor (PVR), has received considerable attention in
recent years because of its intrinsic and extrinsic roles in tumor progression. Although barely …

[HTML][HTML] CD155 cooperates with PD-1/PD-L1 to promote proliferation of esophageal squamous cancer cells via PI3K/akt and MAPK signaling pathways

X Tang, J Yang, A Shi, Y Xiong, M Wen, Z Luo, H Tian… - Cancers, 2022 - mdpi.com
Simple Summary Some immunotherapies, such as anti-PD1 and anti-PD-L1 treatments,
have been used to treat various tumors. However, they are less efficient against esophageal …

[HTML][HTML] CD155 on tumor cells drives resistance to immunotherapy by inducing the degradation of the activating receptor CD226 in CD8+ T cells

M Braun, AR Aguilera, A Sundarrajan, D Corvino… - Immunity, 2020 - cell.com
The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and
promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 …