The hasA gene from Streptococcus equisimilis, which encodes the enzyme hyaluronan
synthase, has been expressed in Bacillus subtilis, resulting in the production of hyaluronic …

Bacillus subtilis was engineered into an efficient hyaluronic acid (HA) producer by
introducing two inducible artificial operons carrying HA synthase gene from Pasteurella …

The hyaluronan (HA) synthase of Group A Streptococci has been identified by transposon
mutagenesis and deletion analysis. The genes for the HA synthase and a recently identified …

Bacillus subtilis strains that can produce hyaluronic acid (HA) were constructed by
integrating the HA synthase gene (hasA) and the UDP‐glucose dehydrogenase gene of …

We previously reported the first cloning of a functional glycosaminoglycan synthase, the
hyaluronan synthase (HAS) from Group A Streptococcus pyogenes (spHAS)(DeAngelis, PL …

An Escherichia coli strain, JM109, was successfully engineered into an efficient hyaluronic
acid (HA) producer by co-expressing the only known class-II HA synthase from a Gram …

Revised Manuscript Received June 13, 1994® abstract: We have recently identified and
cloned the gene for hyaluronan (HA) synthase, hasA, from group A Streptococci [DeAngelis …

Engineering of hyaluronic acid (HA) biosynthetic pathway in recombinant Escherichia coli as
production host is reported in this work. A hyaluronic acid synthase (HAS) gene, sphasA …

Generally recognized as safe, Streptococcus thermophilus was transformed using a plasmid
expressing endogenous hyaluronic acid (HA) synthase genes. A single expression of …

The two hyaluronan synthases (HASs) from Streptococcus pyogenes (spHAS) and
Streptococcus equisimilis (seHAS) were expressed in Escherichia coli as recombinant …