Background Refractory asthma (RA) remains poorly controlled, resulting in high health care
utilization despite guideline-based therapies. Patients with RA manifest higher neutrophilia …

Background Neutrophilic asthma (NA) is a clinically important asthma phenotype, the
cellular and molecular basis of which is not completely understood. Airway macrophages …

Systemic inflammation is reported to be associated with neutrophilic airway inflammation in
asthma, but mechanisms underlying this finding are not well understood. This study aimed to …

Background Severe asthma is a complex disease. Transcriptomic profiling has contributed
to understanding the pathogenesis of asthma, especially type‐2 inflammation. However …

Objective Asthma is a chronic airway inflammatory disease caused by multiple genetic and
environmental factors. This study mainly sought to provide potential therapeutic targets and …

Neutrophilic asthma (NA) is an important asthma inflammatory phenotype associated with
disease severity, airflow limitation, and steroid resistance, and its mechanism is still …

Background Nonsteroidal anti-inflammatory drugs–exacerbated respiratory disease (N-
ERD) is currently classified as a type-2 (T2) immune-mediated disease characterized by …

Asthma pathobiology can be broadly classified by endotypes of type 2-high and type 2-low
disease, with a significant percentage of patients with asthma having a type 2-low endotype …

Background Molecular microbiological analysis of airway samples in asthma has
demonstrated an altered microbiome in comparison to healthy controls. Such changes may …

Airway obstruction, inflammation, and hyperresponsiveness define asthma. This complex
syndrome, however, manifests marked heterogeneity in characterizing disease severity and …