Sex differences in biological aging with a focus on human studies

S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Widespread sex dimorphism in aging and age-related diseases

NK Sampathkumar, JI Bravo, Y Chen, PS Danthi… - Human genetics, 2020 - Springer
Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Sex‐specific aging in animals: perspective and future directions

AM Bronikowski, RP Meisel, PR Biga, JR Walters… - Aging …, 2022 - Wiley Online Library
Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

Sex gap in aging and longevity: can sex chromosomes play a role?

GAB Marais, JM Gaillard, C Vieira, I Plotton… - Biology of sex …, 2018 - Springer
It is well known that women live longer than men. This gap is observed in most human
populations and can even reach 10–15 years. In addition, most of the known super …

Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine

R Ostan, D Monti, P Gueresi, M Bussolotto… - Clinical …, 2016 - portlandpress.com
Data showing a remarkable gender difference in life expectancy and mortality, including
survival to extreme age, are reviewed starting from clinical and demographic data and …

Gender and longevity: why do men die earlier than women? Comparative and experimental evidence

JC Regan, L Partridge - Best practice & research Clinical endocrinology & …, 2013 - Elsevier
Sex differences in lifespan exist world-wide, with women outliving men by more than a
decade in some countries. The gender gap is not a uniquely human phenomenon; most …

Sex differences in longevity and aging

SN Austad - Handbook of the Biology of Aging, 2011 - Elsevier
Publisher Summary This chapter reviews the copious evidence for the robustness of
women's survival advantage, discusses some of the extant evolutionary and mechanistic …

Sex differences in lifespan

SN Austad, KE Fischer - Cell metabolism, 2016 - cell.com
Sex differences in longevity can provide insights into novel mechanisms of aging, yet they
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …

Sex differences in aging: genomic instability

KE Fischer, NC Riddle - The Journals of Gerontology: Series A, 2018 - academic.oup.com
Aging is characterized by decreasing physiological integration, reduced function, loss of
resilience, and increased risk of death. Paradoxically, although women live longer, they …

How to study the impact of sex and gender in medical research: a review of resources

AJ McGregor, M Hasnain, K Sandberg… - Biology of sex …, 2016 - Springer
There is a growing appreciation by the biomedical community that studying the impact of sex
and gender on health, aging, and disease will lead to improvements in human health. Sex …