Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysis

MJ Ruiz, G Siracusano… - Frontiers in …, 2022 - frontiersin.org
The role of the mucosal pulmonary antibody response in coronavirus disease 2019 (COVID-
19) outcome remains unclear. Here, we found that in bronchoalveolar lavage (BAL) samples …

SARS-CoV-2 infection induces robust mucosal antibody responses in the upper respiratory tract

A Escalera, A Rojo-Fernandez, A Rombauts… - Iscience, 2024 - cell.com
Despite multiple research efforts to characterize coronavirus disease 2019 (COVID-19) in
humans, there is no clear data on the specific role of mucosal immunity on COVID-19 …

IgA dominates the early neutralizing antibody response to SARS-CoV-2

D Sterlin, A Mathian, M Miyara, A Mohr… - Science translational …, 2021 - science.org
Humoral immune responses are typically characterized by primary IgM antibody responses
followed by secondary antibody responses associated with immune memory and composed …

Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2–infected individuals reveal unlinked immune signatures

S Ravichandran, G Grubbs, J Tang, Y Lee, C Huang… - Science …, 2021 - science.org
Mucosal immunity plays a key role in prevention of SARS-CoV-2 virus spread to the lungs. In
this study, we evaluated systemic and mucosal immune signatures in asymptomatic SARS …

[HTML][HTML] SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

F Liew, S Talwar, A Cross, BJ Willett, S Scott… - …, 2023 - thelancet.com
Background Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving
limited insights into mucosal defences that prevent viral replication and onward …

Mucosal versus systemic antibody responses to SARS-CoV-2 antigens in COVID-19 patients

B Isho, KT Abe, M Zuo, AJ Jamal, B Rathod, JH Wang… - MedRxiv, 2020 - medrxiv.org
While the antibody response to SARS-CoV-2 has been extensively studied in blood,
relatively little is known about the mucosal immune response and its relationship to systemic …

[HTML][HTML] Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination

A Cagigi, M Yu, B Österberg, J Svensson… - JCI insight, 2021 - ncbi.nlm.nih.gov
Understanding the presence and durability of antibodies against SARS-CoV-2 in the
airways is required to provide insights into the ability of individuals to neutralize the virus …

SARS-CoV-2 convalescence and hybrid immunity elicits mucosal immune responses

O Puhach, M Bellon, K Adea, M Bekliz… - …, 2023 - thelancet.com
Background Mucosal antibodies play a key role in the protection against SARS-CoV-2
infection in the upper respiratory tract, and potentially in limiting virus replication and …

Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19

C Cervia, J Nilsson, Y Zurbuchen, A Valaperti… - Journal of Allergy and …, 2021 - Elsevier
Background Whereas severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-
specific antibody tests are increasingly being used to estimate the prevalence of SARS-CoV …

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

W Hoepel, HJ Chen, CE Geyer… - Science translational …, 2021 - science.org
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …