Objectives Evidence suggests accelerated aging mechanisms in bipolar disorder (BD),
including DNA methylation (DNAm) aging in blood. However, it is unknown whether such …

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the
mechanisms underlying this association are largely unknown. The epigenetic clock has …

There is high mortality among patients with bipolar disorder (BD). Studies have reported
accelerated biological aging in patients with BD. Recently, Horvath and Hannum et al …

Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which
potentially underlies its association with several age-related medical conditions, such as …

Abstract The 10–15-years decrease in life expectancy observed in individuals with bipolar
disorder (BD) has been linked to the concept of accelerated cellular aging. Telomere length …

Psychiatric stress has been associated with accelerated epigenetic aging (ie, when
estimates of cellular age based on DNA methylation exceed chronological age) in both …

Introduction Prior studies have shown inconsistent findings of an association between
depression and epigenetic aging. DNA methylation (DNAm) age acceleration can measure …

Objectives Cognitive impairment is a common feature of late‐life bipolar disorder (BD). Yet,
there is limited information on the biological mechanisms associated with this process. It is …

There is an urgent need to develop molecular biomarkers of brain age in order to advance
our understanding of age related neurodegeneration. Recently, we developed a highly …

Background Little is known about the role of DNA methylation (DNAm) epigenetic age
acceleration in cognitive decline. Using a twin study design, we examined whether DNAm …